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Bacchieri / Della Cioppa

Fundamentals of Clinical Research

Bridging Medicine, Statistics and Operations

Medium: Buch
ISBN: 978-88-470-0491-7
Verlag: Springer Nature Singapore
Erscheinungstermin: 15.12.2006
Lieferfrist: bis zu 10 Tage
Statistical methodology is an essential component of clinical (and biological) - search. Therefore it is not surprising that many textbooks aiming at “explaining” statistical methods to researchers have been published and continue to appear in print. The complexity of the basic issue, that of communication between st- isticians and researchers, is illustrated and discussed very well by the authors of this book in their Introduction. Thus it would be of no benefit to dwell further on this theme and on the difficulty of producing truly effective material. I prefer to start from a personal episode. Way back in 1959, a freshman of the faculty of Statistical Sciences, I found by chance on a stand, the book “Metodi statistici ad uso dei ricercatori”, which was the Italian translation of the famous book by RA Fisher. The textbook for the first course of statistics used that year at of our University had left me perplexed. A student like myself, with a good high school scientific education, was fascinated by the wealth of real life ex- ples, but was unable to reconstruct the thread of logical-mathematical reas- ing, especially the inductive one. The unexpected access to Fisher’s legendary book raised my hopes that I could finally get to the heart of the matter.

Produkteigenschaften


  • Artikelnummer: 9788847004917
  • Medium: Buch
  • ISBN: 978-88-470-0491-7
  • Verlag: Springer Nature Singapore
  • Erscheinungstermin: 15.12.2006
  • Sprache(n): Englisch
  • Auflage: 2007. Auflage 2006
  • Serie: Statistics for Biology and Health
  • Produktform: Gebunden
  • Gewicht: 689 g
  • Seiten: 343
  • Format (B x H x T): 163 x 241 x 27 mm
  • Ausgabetyp: Kein, Unbekannt

Autoren/Hrsg.

Autoren

Bacchieri, Antonella

Della Cioppa, Giovanni

Viability of Biological Phenomena and Measurement Errors.- Distinctive Aspects of a Biomedical Study Observational and Experimental Studies.- Observational Studies.- Defining the Treatment Effect.- Probability, Inference and Decision Making.- The Choice of the Sample.- The Choice of Treatments.- Experimental Design: Fallacy of “Before-After” Comparisons in Uncontrolled Studies.- Experimental Design: the Randomized Blinded Study as an Instrument to Reduce Bias.- Experimental Designs.- Study Variants Applicable to More than One Type of Design: Equivalence Studies, Interim Analyses, Adaptive Plans and Repeated Measurements.- The Drug Development Process and the Phases of Clinical Research.