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Brown

Neurodegeneration and Prion Disease

Medium: Buch
ISBN: 978-1-4899-8688-7
Verlag: Springer US
Erscheinungstermin: 16.09.2014
Lieferfrist: bis zu 10 Tage
This is the first and only book on the subject of prions to cover the cause of cell death in the disease. It covers the full range of competing theories on the subject, from broad description and basic points up to the final details of the basic science.

Produkteigenschaften


  • Artikelnummer: 9781489986887
  • Medium: Buch
  • ISBN: 978-1-4899-8688-7
  • Verlag: Springer US
  • Erscheinungstermin: 16.09.2014
  • Sprache(n): Englisch
  • Auflage: 2005
  • Produktform: Kartoniert, Paperback
  • Gewicht: 739 g
  • Seiten: 473
  • Format (B x H x T): 155 x 235 x 27 mm
  • Ausgabetyp: Kein, Unbekannt

Autoren/Hrsg.

Herausgeber

Brown, David R.

Neuropathology of transmissible spongiform encephalopathies (prion diseases).- Central pathogenesis of prion diseases.- Hereditory prion protein Amyloidoses.- Mouse behavioural studies and what they can teach us about prion diseases.- Electrophysiological approaches to the study of prion diseases.- Prion protein, prion protein-like protein, and neurodegeneration.- Oxidative stress and mitochondrial dysfunction in neurodegeneration of transmissible spongiform encephalopathies (TSEs).- Mechanisms of prion toxicity and their relationship to prion infectivity.- A stone guest on the brain: Death as a prion.- Molecular mechanisms mediating neuronal cell death in experimental models of prion diseases, in vitro.- Processing and mis-processing of the prion protein: Insights into the pathogenesis of familial prion disorders.- Signaling pathways controling prion protein neurotoxicity: Role of endoplasmic reticulum stress-mediated apoptosis.- Cell culture models to unravel prion protein function and aberrancies in TSE.- Insights into the cellular trafficking of prion proteins.- The molecular basis of prion protein-mediated neuronal damage.