This thesis focuses on NHC-catalyzed annulation of nitroalkenes, enals and a,ß-unsaturated carboxylic acids. (1) NHCs were found to be efficient catalysts for the [4+2] annulation of ß-substituted nitroalkenes. The scope of Rauhut–Currier reaction was successfully extended to the most challenging ß-substituted alkenes by this method; (2) Enals were successfully used for [4+2] annulations with azodicarboxylates catalyzed by NHC via ?-addition. Highly enantiopure tetrahydropyridazinones and ?-amino acid derivatives could be easily prepared by subsequent transformations of the resulting dihydropyridazinones. (4) The readily available a,ß-unsaturated carboxylic acids were first successfully employed to generate the a,ß-unsaturated acyl azolium intermediates by using NHC for the enantioselective [3+2] and [3+3] annulations.
Produkteigenschaften
- Artikelnummer: 9789811097348
- Medium: Buch
- ISBN: 978-981-10-9734-8
- Verlag: Springer Nature Singapore
- Erscheinungstermin: 07.07.2018
- Sprache(n): Englisch
- Auflage: Softcover Nachdruck of the Original 1. 2017 Auflage 2018
- Serie: Springer Theses
- Produktform: Kartoniert, Previously published in hardcover
- Gewicht: 204 g
- Seiten: 123
- Format (B x H x T): 156 x 234 x 8 mm
- Ausgabetyp: Kein, Unbekannt