Nano and Cell Mechanics

Fundamentals and Frontiers

Medium: Buch

ISBN: 978-1-118-46039-9

Verlag: Wiley

Erscheinungstermin: 29.01.2013

154,50 € 144,39 € (zzgl. MwSt.)

Lieferfrist: bis zu 10 Tage

Research in nano and cell mechanics has received much attention from the scientific community as a result of society needs and government initiatives to accelerate developments in materials, manufacturing, electronics, medicine and healthcare, energy, and the environment. Engineers and scientists are currently engaging in increasingly complex scientific problems that require interdisciplinary approaches. In this regard, studies in this field draw from fundamentals in atomistic scale phenomena, biology, statistical and continuum mechanics, and multiscale modeling and experimentation. As a result, contributions in these areas are spread over a large number of specialized journals, which prompted the Editors to assemble this book.

Nano and Cell Mechanics: Fundamentals and Frontiers brings together many of the new developments in the field for the first time, and covers fundamentals and frontiers in mechanics to accelerate developments in nano- and bio-technologies.

Key features:

* Provides an overview of recent advances in nano and cell mechanics.

* Covers experimental, analytical, and computational tools used to investigate biological and nanoscale phenomena.

* Covers fundamentals and frontiers in mechanics to accelerate developments in nano- and bio-technologies.

* Presents multiscale-multiphysics modeling and experimentation techniques.

* Examines applications in materials, manufacturing, electronics, medicine and healthcare.

Nano and Cell Mechanics: Fundamentals and Frontiers is written by internationally recognized experts in theoretical and applied mechanics, applied physics, chemistry, and biology. It is an invaluable reference for graduate students of nano- and bio-technologies, researchers in academia and industry who are working in nano and cell mechanics, and practitioners who are interested in learning about the latest analysis tools. The book can also serve as a text for graduate courses in theoretical and applied mechanics, mechanical engineering, materials science, and applied physics.

Produkteigenschaften

Artikelnummer: 9781118460399
Medium: Buch
ISBN: 978-1-118-46039-9
Verlag: Wiley
Erscheinungstermin: 29.01.2013
Sprache(n): Englisch
Auflage: 6. Auflage 2013
Serie: Microsystem and Nanotechnology Series
Produktform: Gebunden
Gewicht: 916 g
Seiten: 506
Format (B x H x T): 170 x 250 x 29 mm
Ausgabetyp: Kein, Unbekannt

Themen

About the Editors xiii

List of Contributors xv

Foreword xix

Series Preface xxi

Preface xxiii

Part One BIOLOGICAL PHENOMENA

1 Cell-Receptor Interactions 3
David Lepzelter and Muhammad Zaman

1.1 Introduction 3

1.2 Mechanics of Integrins 4

1.3 Two-Dimensional Adhesion 7

1.4 Two-Dimensional Motility 9

1.5 Three-Dimensional Adhesion 11

1.6 Three-Dimensional Motility 12

1.7 Apoptosis and Survival Signaling 13

1.8 Cell Differentiation Signaling 13

1.9 Conclusions 14

References 15

2 Regulatory Mechanisms of Kinesin and Myosin Motor Proteins: Inspiration for Improved Control of Nanomachines 19
Sarah Rice

2.1 Introduction 19

2.2 Generalized Mechanism of Cytoskeletal Motors 19

2.3 Switch I: A Controller of Motor Protein and G Protein Activation 21

2.4 Calcium-Binding Regulators of Myosins and Kinesins 23

2.5 Phospho-Regulation of Kinesin and Myosin Motors 262.6 Cooperative Action of Kinesin and Myosin Motors as a "Regulator" 28

2.7 Conclusion 29

References 30

3 Neuromechanics: The Role of Tension in Neuronal Growth and Memory 35
Wylie W. Ahmed, Jagannathan Rajagopalan, Alireza Tofangchi, and Taher A. Saif

3.1 Introduction 35

3.2 Tension in Neuronal Growth 41

3.3 Tension in Neuron Function 48

3.4 Modeling the Mechanical Behavior of Axons 52

3.5 Outlook 58

References 58

Part Two NANOSCALE PHENOMENA

4 Fundamentals of Roughness-Induced Superhydrophobicity 65
Neelesh A. Patankar

4.1 Background and Motivation 65

4.2 Thermodynamic Analysis: Classical Problem (Hydrophobic to Superhydrophobic) 67

4.3 Thermodynamic Analysis: Classical Problem (Hydrophilic to Superhydrophobic) 84

4.4 Thermodynamic Analysis: Vapor Stabilization 86

4.5 Applications and Future Challenges 90

Acknowledgments 91

References 91

5 Multiscale Experimental Mechanics of Hierarchical Carbon-Based Materials 95
Horacio D. Espinosa, Tobin Filleter, and Mohammad Naraghi

5.1 Introduction 95

5.2 Multiscale Experimental Tools 97

5.3 Hierarchical Carbon-Based Materials 106

5.4 Concluding Remarks 120

References 123

6 Mechanics of Nanotwinned Hierarchical Metals 129
Xiaoyan Li and Huajian Gao

6.1 Introduction and Overview 129

6.2 Microstructural Characterization and Mechanical Properties of Nanotwinned Materials 134

6.3 Deformation Mechanisms in Nanotwinned Metals 145

6.4 Concluding Remarks 156

References 157

7 Size-Dependent Strength in Single-Crystalline Metallic Nanostructures 163
Julia R. Greer

7.1 Introduction 163

7.2 Background 164

7.3 Sample Fabrication 170

7.4 Uniaxial Deformation Experiments 175

7.5 Discussion and Outlook on Size-Dependent Strength in Single-Crystalline Metals 178

7.6 Conclusions and Outlook 184

References 185

Part Three EXPERIMENTATION

8 In-Situ TEM Electromechanical Testing of Nanowires and Nanotubes 193
Horacio D. Espinosa, Rodrigo A. Bernal, and Tobin Filleter

8.1 Introduction 193

8.2 In-Situ TEM Experimental Methods 197

8.3 Capabilities of In-Situ TEM Applied to One-Dimensional Nanostructures 212

8.4 Summary and Outlook 220

Acknowledgments 221

References 221

9 Engineering Nano-Probes for Live-Cell Imaging of Gene Expression 227
Gang Bao, Brian Wile, and Andrew Tsourkas

9.1 Introduction 227

9.2 Molecular Probes for RNA Detection 229

9.3 Probe Design, Imaging, and Biological Issues 239

9.4 Delivery of Molecular Beacons 244

9.5 Engineering Challenges and Future Directions 248

Acknowledgments 249

References 249

10 Towards High-Throughput Cell Mechanics Assays for Research and Clinical Applications 255
David R. Myers, Daniel A. Fletcher, and Wilbur A. Lam

10.1 Cell Mechanics Overview 255

10.2 Bulk Assays 262

10.3 Single-Cell Techniques 268

10.4 Existing High-Throughput Cell Mechanical-Based Assays 274

10.5 Cell Mechanical Properties and Diseases 280

References 284

11 Microfabricated Technologies for Cell Mechanics Studies 293
Sri Ram K. Vedula, Man C. Leong, and Chwee T. Lim

11.1 Introduction 293

11.2 Microfabrication Techniques 294

11.3 Applications to Cell Mechanics 298

11.4 Conclusions 307

References 307

Part Four MODELING

12 Atomistic Reaction Pathway Sampling: The Nudged Elastic BandMethod and Nanomechanics Applications 313
Ting Zhu, Ju Li, and Sidney Yip

12.1 Introduction 313

12.2 The NEB Method for Stress-Driven Problems 315

12.3 Nanomechanics Case Studies 324

12.4 A Perspective on Microstructure Evolution at Long Times 332

References 336

13 Mechanics of Curvilinear Electronics 339
Shuodao Wang, Jianliang Xiao, Jizhou Song, Yonggang Huang, and John A. Rogers

13.1 Introduction 339

13.2 Deformation of Elastomeric Transfer Elements during Wrapping Processes 342

13.3 Buckling of Interconnect Bridges 347

13.4 Maximum Strain in the Circuit Mesh 351

13.5 Concluding Remarks 355

Acknowledgments 355

References 355

14 Single-Molecule Pulling: Phenomenology and Interpretation 359
Ignacio Franco, Mark A. Ratner, and George C. Schatz

14.1 Introduction 359

14.2 Force-Extension Behavior of Single Molecules 360

14.3 Single-Molecule Thermodynamics 364

14.4 Modeling Single-Molecule Pulling Using Molecular Dynamics 370

14.5 Interpretation of Pulling Phenomenology 376

14.6 Summary 384

Acknowledgments 385

References 385

15 Modeling and Simulation of Hierarchical Protein Materials 389
Tristan Giesa, Graham Bratzel, and Markus J. Buehler

15.1 Introduction 389

15.2 Computational and Theoretical Tools 391

15.3 Case Studies 400

15.4 Discussion and Conclusion 406

Acknowledgments 406

References 406

16 Geometric Models of Protein Secondary-Structure Formation 411
Hendrik Hansen-Goos and Seth Lichter

16.1 Introduction 411

16.2 Hydrophobic Effect 412

16.3 Prior Numerical and Coarse-Grained Models 415

16.4 Geometry-Based Modeling: The Tube Model 416

16.5 Morphometric Approach to Solvation Effects 422

16.6 Discussion, Conclusions, Future Work 429

Acknowledgments 433

References 433

17 Multiscale Modeling for the Vascular Transport of Nanoparticles 437
Shaolie S. Hossain, Adrian M. Kopacz, Yongjie Zhang, Sei-Young Lee, Tae-Rin Lee, Mauro Ferrari, Thomas J.R. Hughes, Wing Kam Liu, and Paolo Decuzzi

17.1 Introduction 437

17.2 Modeling the Dynamics of NPs in the Macrocirculation 438

17.3 Modeling the NP Dynamics in the Microcirculation 448

17.4 Conclusions 456

Acknowledgments 456

References 457

Index 461

Nano and Cell Mechanics

Beschreibung

Autoren/Hrsg.

Inhalt

Produkteigenschaften

Themen

Espinosa, Horacio D

Bao, Gang

Site Breadcrumb

Nano and Cell Mechanics

Beschreibung

Autoren/Hrsg.

Inhalt

Produkteigenschaften

Themen

Autoren/Hrsg.

Espinosa, Horacio D

Bao, Gang