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Fainsod / Moody

Xenopus

From Basic Biology to Disease Models in the Genomic Era

Medium: Buch
ISBN: 978-0-367-50527-1
Verlag: Taylor & Francis
Erscheinungstermin: 20.04.2022
Lieferfrist: bis zu 10 Tage
This book focuses on the amphibian, Xenopus, one of the most commonly used model animals in the biological sciences. Over the past 50 years, the use of Xenopus has made possible many fundamental contributions to our knowledge in cell biology, developmental biology, molecular biology, and neurobiology. In recent years, with the completion of the genome sequence of the main two species and the application of genome editing techniques, Xenopus has emerged as a powerful system to study fundamental disease mechanisms and test treatment possibilities. Xenopus has proven an essential vertebrate model system for understanding fundamental cell and developmental biological mechanisms, for applying fundamental knowledge to pathological processes, for deciphering the function of human disease genes, and for understanding genome evolution.

Key Features

- Provides historical context of the contributions of the model system

- Includes contributions from an international team of leading scholars

- Presents topics spanning cell biology, developmental biology, genomics, and disease model

- Describes recent experimental advances

- Incorporates richly illustrated diagrams and color images

Related Titles

Green, S. L. The Laboratory Xenopus sp. (ISBN 978-1-4200-9109-0)

Faber, J. & P. D. Nieuwkoop. Normal Table of Xenopus laevis (Daudin): A Systematical & Chronological Survey of the Development from the Fertilized Egg till the End of Metamorphosis (ISBN 978-0-8153-1896-5)

Jarret, R. L. & K. McCluskey. The Biological Resources of Model Organisms (ISBN 978-1-0320-9095-5)

The Open Access version of this book, available at www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.

Produkteigenschaften


  • Artikelnummer: 9780367505271
  • Medium: Buch
  • ISBN: 978-0-367-50527-1
  • Verlag: Taylor & Francis
  • Erscheinungstermin: 20.04.2022
  • Sprache(n): Englisch
  • Auflage: 1. Auflage 2022
  • Produktform: Gebunden
  • Gewicht: 1179 g
  • Seiten: 360
  • Format (B x H): 210 x 280 mm
  • Ausgabetyp: Kein, Unbekannt

Autoren/Hrsg.

Herausgeber

Fainsod, Abraham

Moody, Sally A.

Section I. 1. A quick history of Xenopus. 2. The study of cell division controla and DNA replication in Xenopus egg extracts. 3. Maternal gene control of embryogenesis: germ cell determination and germ layer formation. 4. Signaling components in dorsal-ventral patterning and the Organizer. 5. Signaling pathways in anterior-posterior patterning. 6. Wnt signaling in tissue differentiation and morphogenesis. 7. Multiple functions of Notch signaling during early embryogenesis. 8. The development and evolution of the vertebrate neural crest: Insights from Xenopus. 9. The use of Xenopus oocytes to study the biophysics and pharmacological properties of receptors and channels. Section II. 10. The continuing evolution of the Xenopus genome. 11. Dynamics of chromatin remodeling during Xenopus development. 12. Gene regulatory networks controlling Xenopus embryogenesis. 13. The development of high-resolution proteomic analyses in Xenopus. 14. Advances in genome editing tools. Section III. 15. Formation of the left-right axis: insights from the Xenopus model. 16. Discovering the function of congenital heart disease genes. 17. Craniofacial development and disorders - contributions of Xenopus. 18. Modeling digestive and respiratory system development and disease in Xenopus. 19. Functional neurobiology and insights into human disease. 20. Leaping towards the understanding of spinal cord regeneration. 21. Studying tumor formation and regulation in Xenopus. 22. Xenopus: a model to study natural genetic variation and its disease implications. 23. Using Xenopus to understand pluripotency and reprogram cells for therapeutic use.













Maternal gene control of embryogenesis. Chapter 8: Sex determination in Xenopus. Section II: Gene Discovery and Disease. Chapter 9: Xenopus and the discovery of developmental genes. Chapter 10: Systems Biology of Xenopus Embryogenesis. Chapter 11: Gene regulatory networks in craniofacial development. Chapter 12: Using Xenopus to discover regulation of GI development and disease. Chapter 13: Using Xenopus to discover the function of congenital heart disease genes. Chapter 14: Using Xenopus to discover the function of congenital kidney disease genes. Chapter 15: Using Xenopus to study genes involved in cancers. Section III: Evolution. Chapter 16: Evolution of amphibians. Chapter 17: Evolution of Xenopus communication. Chapter 18: Evolution of the immune system. Chapter 19: Evolution of the left-right axis. Chapter 20: Evolution of the Xenopus genome.