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Elkabets / Yarden

Resistance to Anti-Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways

Medium: Buch
ISBN: 978-3-030-09817-9
Verlag: Springer International Publishing
Erscheinungstermin: 02.02.2019
Lieferfrist: bis zu 10 Tage
This volume comprehensively covers the multiplicity and diversity of mechanisms underlying patient resistance to currently approved anti-cancer drugs, including tyrosine kinase inhibitors and monoclonal antibodies, blockers of growth factor receptors and their downstream pathways, which play essential functions in cancer progression. Each chapter will cover a specific group of targets and the cognate drugs, along with molecular modes of innate and evolving resistance.

Produkteigenschaften


  • Artikelnummer: 9783030098179
  • Medium: Buch
  • ISBN: 978-3-030-09817-9
  • Verlag: Springer International Publishing
  • Erscheinungstermin: 02.02.2019
  • Sprache(n): Englisch
  • Auflage: Softcover Nachdruck of the original 1. Auflage 2018
  • Serie: Resistance to Targeted Anti-Cancer Therapeutics
  • Produktform: Kartoniert, Paperback
  • Gewicht: 406 g
  • Seiten: 242
  • Format (B x H x T): 155 x 235 x 15 mm
  • Ausgabetyp: Kein, Unbekannt

Autoren/Hrsg.

Herausgeber

Elkabets, Moshe

Yarden, Yosef

Resistance of colorectal tumors to anti-EGFR antibodies.- Resistance of lung cancer to kinase inhibitors specific to EGFR or ALK.- Mechanisms of action and resistance of trastuzumab in breast cancer.- Mechanisms of resistance to molecular therapies targeting the HGF/MET axis.- RAF, MEK and ERK inhibitors as anti-cancer drugs: intrinsic and acquired resistance as a major therapeutic challenge.- Mechanisms of resistance to PI3K and AKT inhibitors.- Sensitivity and resistance to BH3 mimetics in cancer therapy.- Resistance mechanisms to cyclin-dependent kinase inhibitors.- Resistance to inhibitors of angiogenesis.