fachmedien.de - spezialisierte Fachinformationen für Studium und Beruf
fachmedien.de - spezialisierte Fachinformationen für Studium und Beruf
fachmedien.de - spezialisierte Fachinformationen für Studium und Beruf
fachmedien.de - spezialisierte Fachinformationen für Studium und Beruf
fachmedien.de - spezialisierte Fachinformationen für Studium und Beruf

Site Breadcrumb

Verkauf durch Sack Fachmedien

Ulinski

Cerebral Cortex

Models of Cortical Circuits

Medium: Buch
ISBN: 978-1-4613-7223-3
Verlag: Springer US
Erscheinungstermin: 27.09.2012
In den Warenkorb
Lieferfrist: bis zu 10 Tage
Auf die Merkliste Drucken

Leseprobe

Kundenservice

Telefon: +49 69 943 329 50
E-Mail: webshop@sack.de

» Kontaktformular

Bücher

Unsere Bücher sind versandkostenfrei erhältlich

Rücksendung

kostenlose Rücksendungen für Bücher

Noch Fragen?

Unser Kundenservice hilft gerne weiter
long-termplasticityandwithapproachestolearningandmemorybasedonmodifica­ tionofHebbiansynapsesarenotconsidered. Relativelyabstractattemptstounder­ standhigherlevelandcognitiveprocessesbasedonneuralnetsrepresentasecond, majorareaofworkthatisnottreated. Modelsofcognitiveprocessesbasedon dynamicalsystemsmethodsinwhichnoattemptismadetoincludethebiophysical featuresofindividualneuronsarealsonotconsidered. vii viii Thetenmajorchaptersfallintothreegroups. Thefirstgroupdealswith compartmentalmodelsofindividualcorticalneurons. LyleBorg-Grahamprovides PREFACE anintroductiontothemethodsinvolvedinconstructingcompartmentalmodels andthenreviewstheexistingmodelsofhippocampalpyramidalcells. Becauseof theeffectivenessofhippocampalslicepreparations,theseneuronshavewell-ehar­ acterizedbiophysicalproperties. Thischapterillustrateshowcompartmentalmod­ elscanbeusedtosynthesizeexperimentaldataandprovideanintegrativeviewof thepropertiesofindividualneurons. PaulRhodescontinuesthethemebyfocusing ontheroleofvoltage-gatedchannelslocatedonthedendritesofcorticalneurons. Thisisanareainwhichtechnologicaladvancesinthevisualizationofneuronsin slicepreparationsbasedoninfraredmicroscopyhavegreatlyexpandedtheinfor­ mationavailableondendriticfunctioninjustafewyears. Thechapterbothreviews theexperimentaldataonactivedendriticconductancesandemphasizestheirpo­ tentialfunctionalroles. Thesecondgroupofchaptersdealwiththegenerationofreceptivefield propertiesofneuronswithinvisualcortex. Theyaddressissuesstemmingfromthe originalattempttounderstandhowthereceptivefieldpropertiesofneuronsincat andmonkeyprimaryvisualcortexaregeneratedbyinteractionsbetweengenicu­ lateafferentsandcorticalneurons. ThechapterbyFlorentinWorgotterevaluates modelsthathavebeenusedtoanalyzethegenerationofreceptivefieldproperties. RodneyDouglasandhiscolleaguesaddressaspecificsetofissuesdealingwiththe roleofintracorticalexcitationmediatedbypyramidalcellcollaterals. Animportant featureofthischapterisitsrelationtoattempttoconstructfabricatedcircuitsthat duplicatethefunctionsofcorticalcircuits. ThechapterbyPhilipUlinskifocuseson thegenerationofmotion-selectivepropertiesincorticalneurons. Itseekstoidenti­ tycellularmechanismsusedbyneuronsthatrespondpreferentiallytovisualstimuli movingwithparticularspeedsordirections. MatteoCarandiniandhiscolleagues discussthefeatureofcorticalneurons,knownasgaincontrol,thatallowsneurons torespondeffectivelytovisualstimulibypoolinginformationacrosspopulationsof corticalneurons. ThechapterbyHughWilsondealswiththereceptivefieldproper­ tiesofextrastriateareasandintroducesnewworkanalyzingface-selectiveneurons. Thefinalsetofchaptersconsidermodelsofensemblesofthalamicandcortical neurons. ThechapterbyWilliamLyttonandElizabethThomasusesthetheoryof dynamicalsystemstoanalyzethetemporalrelationshipsbetweenthalamicand corticalneurons. Animportantfeatureoftheinteractionbetweenthalamusand cortexisthepresenceofoscillationsthatdependinpartuponthevoltage-gated conductancespresentonindividualneuronsandinpartonthestructureofthe overallnetwork. PaulBushcontinuesthisemphasisonoscillationsbydiscussinga modelthatdealswiththegenerationofsynchronizedoscillationsinvisualcortex. Oscillationsofthiskindhaveattractedsubstantialattentioninrecentyearsbecause oftheirpotentialroleincognitiveprocesses. Thelastchapter,byMichaelHasselmo andChristianeLinster,reviewstheirworkonmodelingpiriformcortex,emphasiz­ ingtheroleofcholinergicmechanismsinmodulatingtheactivityofcorticalneu­ rons. Anattempthasbeenmadethroughouttomakethevolumeaccessibleto readerswithminimalmathematicalbackgrounds. Thevolumethusbeginswitha shorthistoryofmodelsofcorticalneuronsandcircuitrythatintroducestheprinci­ palmodelingstyles. ThechaptersbyWorgotterandUlinskicontainmoreextensive ix introductionstosomeofthemodelingmethodsthathavebeenusedtostudyvisual cortex,andthemathematicallychallengedreaderwillfindthatthechapterby PREFACE LyttonandThomascontainsareadableintroductiontotheuseofdynamical systemstheoryinneurobiology. PhilipS. Ulinski EdwardG. Jones Chicago and Davis Contents Chapter 1 ModelingCorticalCircuitry:AHistoryandProspectus PhilipS. Ulinski 1. Introduction ". 1 2. LorentedeNothroughDynamicalSystemsModels. 2 2. 1. LorentedeNo. 2 2. 2. CellAssembliesandNeuralNets. 3 2. 3. DynamicSystemsModels. 8 3. HodgkinandHuxleythroughNetworkModels. 11 3. 1. HodgkinandHuxley. 11 3. 2. WilfridRall. 11 3. 3. SoftwarePackages. 13 3. 4. RealisticModelsofCorticalNetworks. 14 4. Prospectus. 14 5. References. 15 Chapter 2 InterpretationsofDataandMechanismsforHippocampalPyramidal CellModels LyleJ Borg-Graham 1. Introduction. 19 1. 1. NeuronModelEvolution-followingElectrophysiology. 19 1. 2. NeuronModelEvaluation-followingtheParameters. 21 1. 3. WhyHippocampus? 21 1. 4. OrganizationofThisChapter. 22 xi xii 2. TheDatabaseforSingle-NeuronModels. 23 2. 1. VoltageClampversusCurrentClamp. 23 CONTENTS 2. 2. Single-ChannelversusMacroscopicCurrents. 24 2. 3. TypeofPreparation. 24 2. 4. KineticandPharmacologicalDissection. 25 2. 5. TemperatureDependence. 26 2. 6. AgeDependence. 27 2. 7. HippocampalSubfieldDependence. 27 2. 8. DifferencesinFiringPropertiesbetweenSharpversusPatch Recordings. 28 2. 9. TheMeasuredVoltage.

Produkteigenschaften

  • Artikelnummer: 9781461372233
  • Medium: Buch
  • ISBN: 978-1-4613-7223-3
  • Verlag: Springer US
  • Erscheinungstermin: 27.09.2012
  • Sprache(n): Englisch
  • Auflage: Softcover Nachdruck of the original 1. Auflage 1999
  • Serie: Cerebral Cortex
  • Produktform: Kartoniert, Paperback
  • Gewicht: 1112 g
  • Seiten: 573
  • Format (B x H x T): 178 x 254 x 33 mm
  • Ausgabetyp: Kein, Unbekannt

Themen

Autoren/Hrsg.

Herausgeber

Ulinski, Philip S.

1 Modeling Cortical Circuitry: A History and Prospectus.- 1. Introduction.- 2. Lorente de Nó through Dynamical Systems Models.- 3. Hodgkin and Huxley through Network Models.- 4. Prospectus.- 5. References.- 2 Interpretations of Data and Mechanisms for Hippocampal Pyramidal Cell Models.- 1. Introduction.- 2. The Database for Single-Neuron Models.- 3. Strategies for Single-Neuron Models.- 4. Anatomy and the Model: Data and Methods.- 5. The Linear Model: Data and Methods.- 6. Phenomenological Templates.- 7. Review of Hippocampal Models.- 8. Channel Models.- 9. Ionic Concentration Dynamics.- 10. Nonsynaptic Channels of Hippocampal Pyramidal Cells.- 11. HPC Sodium Channels.- 12. HPC Calcium Channels.- 13. HPC Potassium Channels.- 14. Nonspecific Cation and Chloride Currents.- 15. Simulations of HPC Properties with the Working Model.- 16. References.- 3 Functional Implications of Active Currents in the Dendrites of Pyramidal Neurons.- 1. Introduction.- 2. Historical Perspective.- 3. Amplification of Synaptic Inputs.- 4. Compartment Model Simulations of Amplification.- 5. Effects of Dendritic Active Currents on EPSP Shape.- 6. The Effect of Dendritic Active Currents in Shaping the Intrinsic Firing Properties of Pyramidal Cells.- 7. Effects of Potassium Currents.- 8. Linking Firing of the Soma to Depolarization at Distal Synapses and the Implementation of Hebb’s Hypothesis.- 9. Apologies.- 10. Concluding Observations.- 11. References.- 4 Comparing Different Modeling Approaches of Visual Cortical Cell Characteristics.- 1. Introduction.- 2. Foundations.- 3. Models of Cortical Orientation Specificity.- 4. Concluding Remarks.- 5. Appendix.- 6. References.- 5 The Role of Recurrent Excitation in Neocortical Circuits.- 1. Introduction.- 2. Wiring Neocortical Circuits.- 3. CanonicalMicrocircuits.- 4. Units of Construction of the Basic Cortical Circuit.- 5. The Neuronal Components of Layer 4.- 6. Computation of Orientation.- 7. Noise and Restoration.- 8. References.- 6 Neural Mechanisms Underlying the Analysis of Moving Visual Stimuli.- 1. Introduction.- 2. A Primer of Basic Concepts.- 3. Neural Mechanisms: Mammals.- 4. Neural Mechanisms: Turtles.- 5. Conclusions and Future Directions.- 6. References.- 7 Linearity and Gain Control in VI Simple Cells.- 1. Introduction.- 2. The Linear Model of Simple Cells.- 3. Some Linear Properties of Simple Cells.- 4. Biophysics of the Linear Model.- 5. Some Nonlinear Properties of Simple Cells.- 6. The Normalization Model of Simple Cells.- 7. Testing the Normalization Model.- 8. Biophysical Plausibility of the Normalization Model.- 9. Conclusions.- 10. References.- 8 Non-Fourier Cortical Processes in Texture, Form, and Motion Perception.- 1. Introduction.- 2. Analysis of Texture Boundaries by Non-Fourier Mechanisms.- 3. Area V4 Neurons and Form Vision.- 4. Two-Dimensional Motion.- 5. Discussion.- 6. References.- 9 Modeling Thalamocortical Oscillations.- 1. Slow Thalamic Rhythms.- 2. Thalamus as Magnet for Modeling—Dynamics and Neural Systems.- 3. Early Modeling Predicted a Role for Inhibitory Phasing.- 4. Modeling the T Channel.- 5. Modeling the Low-Threshold Spike.- 6. The Basic Two-Neuron Network.- 7. The Search for Origins: Whence Spindling?.- 8. Synchrony and Spread of Network Activity.- 9. Summary and Conclusions.- 10. References.- 10 Realistic Network Models of Synchronized Oscillations in Visual Cortex.- 1. Introduction.- 2. Model Structure.- 3. Model Results.- 4. Conclusion.- 5. References.- 11 Modeling the Piriform Cortex.- 1. Introduction.- 2. Summary of Data Being Modeled.- 3. Modeling ofPhysiological Data.- 4. Modeling of Functional Hypotheses.- 5. Summary and Future Directions.- 6. References.